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KMID : 0812020070130010026
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Korean Journal of Neurogastroenterology and Motility
2007 Volume.13 No. 1 p.26 ~ p.30
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Prevalence of Tropheryma whippelii DNA in Patients with Reflux Esophagitis or Irritable Bowel Syndrome
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Kim Jung-Mi
Jun Jae-Bum
Lee Oh-Young
Lee Hang-Lak
Na Young-In
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Abstract
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Background/Aims: Tropheryma whippelii is the causative agent of Whipple’s disease, and it is difficult to diagnose this systemic illness. Little is known about the epidemiology of T. whippelii and its prevalence in people who are without any clinical signs of Whipple’s disease. Patients and
Methods: We screened a total of 89 patients with reflux esophagitis (53 patients) and diarrhea-dominant irritable bowel syndrome (36 patients) for T. whippelii DNA and we compared them with 129 healthy controls in order to check whether T. whippelii might be a risk factor for common gastrointestinal diseases. We detected the 23S rDNA of T. whippelii in salivary samples with using a specific semi-nested PCR.
Results: We found one patient to be PCR-positive in the saliva, so the prevalence rate of T. whippelii was 1.1%. Additionally, when compared with the 129 healthy controls, there was no significant difference in the prevalence rate. Both reflux esophagitis and irritable bowel syndrome were not associated with a PCR-positive test for T. whippelii.
Conclusions: The prevalence of T. whippelii DNA in patients with reflux esophagitis or irritable bowel syndrome and in the healthy control patients is very low.
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KEYWORD
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Tropheryma whippelii, Prevalence, Reflux esophagitis, Irritable bowel syndrome
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